Statins that penetrate blood brain barrier
Statins as neuroprotectants: a comparative in vitro study of lipophilicity, blood- brain-barrier penetration, lowering of brain cholesterol, and decrease of neuron.
Lipophilic or Hydrophilic Nature of Statins Is Important
7 Sep However, the effects of statins of differing blood-brain barrier (BBB) the effect of statins on these indices as a function of BBB penetration.
studies, including differing blood-brain barrier permeabilities among statins, the in part by differential abilities of statins to cross the blood-brain barrier (BBB ).
Description:Abstract There is growing evidence to support the hypothesis that statins may act as neuroprotectants in several neuropathological conditions, including Alzheimer's disease. The mechanisms for neuroprotection are only partially understood, however, and pleiotropic phenomena could be involved. We have made a comparative study of 9 statins lovastatin, mevastatin, pravastatin, simvastatin, cerivastatin, atorvastatin, fluvastatin, pitavastatin, and rosuvastatin , analyzing several parameters that could be related to neuroprotection, such as chemical structure, lipophilicity, potential blood-brain-barrier penetration BBB , 3-hydroxymethylglutaryl co-enzyme A reductase inhibition, cholesterol modulation in neurons, glia, and human hepatocyte cell lines, and protection against neurodegeneration caused by tau hyperphosphorylation induced by okadaic acid. Our results indicate that monacolin J derivatives natural and semi-synthetic statins are the best candidates for the prevention of neurodegenerative conditions due to their higher potential BBB penetration capacity, cholesterol lowering effect on neurons with a satisfactory safety profile, and in vitro protection against cell death caused by okadaic acid in culture.